Dana-Farber Cancer Institute

Nathan F Moore

Uncovering the anti-apoptotic mechanism of mutated ALK in neuroblastoma

Brain, nervous system

Pediatric oncology or childhood cancer

Nathanael Schiander Gray

Tumor Cell Biology Training Program

Melanoma of skin All cancers but non-melanoma skin cancer

Peter S Hammerman

Therapeutic targeting of Fibroblast Growth Factor Receptors in Squamous Cancers

Trachea, bronchus and lung Other pharynx Oesophagus Nasopharynx Lip, oral cavity Larynx

William C Hahn

The Dana-Farber Cancer Institute Cancer Target Discovery and Development Center

Melanoma of skin All cancers but non-melanoma skin cancer

Thomas M Roberts

Targeting the p110beta isoform of PI3 kinase in prostate cancer

Prostate

Pasi A Janne

Targeting ALK and ROS1 in Lung Cancer

Trachea, bronchus and lung

Martin E Hemler

Support of carcinoma metastasis by integrin a6-CD151-PKC complexes

Breast

Levi A. Garraway

Systematic Genetic Characterization of African American Prostate Cancer

Prostate

Pathology

Kwok Kin Wong

Therapeutic strategies for specific subsets of KRAS mutant lung cancers

Trachea, bronchus and lung

Kornelia Polyak

Targeting intratumor heterogeneity in breast cancer

Breast

Kimberly Stegmaier

Validating Syk as a Target for AML Therapy

Leukaemia

Kenneth C. Anderson

SPORE in Multiple Myeloma

Multiple myeloma and immunoproliferative diseases

Julie Aurore Losman

The Role of EglN1 and HIF in Normal Hematopoiesis and in Leukemia

Leukaemia

Irene M. Ghobrial

The role of miRNA15a and 16-1 in Multiple Myeloma

Multiple myeloma and immunoproliferative diseases

Irene M. Ghobrial

Stroma-mediated clonal evolution in Multiple Myeloma

Multiple myeloma and immunoproliferative diseases

George Rani E

The ALK receptor tyrosine kinase as a therapeutic target in neuroblastoma

Brain, nervous system

Levi A. Garraway

The Use of Whole-Exome Sequencing to Guide the Care of Cancer Patients

Melanoma of skin All cancers but non-melanoma skin cancer

Eric P Winer

SPORE: Dana-Farber/Harvard Cancer Center SPORE in Breast Cancer

Breast

David A Barbie

Targeting the cytokine circuitry of KRAS-driven lung cancer

Trachea, bronchus and lung

Dan Landau

The role of epigenetic heterogeneity in CLL evolution

Leukaemia

Charles S Fuchs

SPORE: DF/HCC SPORE in GASTROINTESTINAL CANCER

Stomach Colorectum

Charles Roberts

The function of Snf5, an epigenetic tumor suppressor

Melanoma of skin All cancers but non-melanoma skin cancer

Catherine Ju-Ying Wu

The role of the SF3B1 splicing factor in chronic lymphocytic leukemia

Leukaemia

Brian Crompton

Targeting FAK and integrin signaling in preclinical models of Ewing sarcoma

Sarcoma

Andrew A Lane

Targeting Chromatin Modifications in Leukemia with Trisomy 21

Leukaemia

Kimmie Ng

Role of Vitamin D, Inflammation, and Energy Balance in Colorectal Cancer Survival

Colorectum

Pathology

Emanuele Mazzola

Risk assessment in atypical breast hyperplasia

Breast

Eliezer M Van Allen

Resistance to Emerging Androgen Deprivation Therapies in Prostate Cancer

Prostate

Stuart H Orkin

Research Training in Pediatric Oncology

Melanoma of skin All cancers but non-melanoma skin cancer

Pediatric oncology or childhood cancer

Kristopher Andrew Sarosiek

Regulation of apoptotic priming and competence in healthy and cancerous cells

Melanoma of skin All cancers but non-melanoma skin cancer

William C Hahn

Regulation and function of IKKe in breast cancer initiation and maintenance

Breast

Pathology

Matthew L. Meyerson

Protein Kinase Therapeutic Targets for Non-Small Cell Lung Carcinoma

Trachea, bronchus and lung

Anthony G Letai

Probing mitochondria and personalizing leukemia therapy with BH3 profiling

Leukaemia

Daphne A Haas-Kogan

Precision Medicine For Pediatric Low-Grade Gliomas

Brain, nervous system

Pediatric oncology or childhood cancer

David Marc Weinstock

Polysomy 21 in Acute Lymphoblastic Leukemia

Leukaemia

Jarrod A. Marto

Phosphoproteomic signatures for early detection and stratification of AML

Leukaemia

Catherine Ju-Ying Wu

Personal tumor neoantigens for immunity against chronic lymphocytic leukemia

Leukaemia

Donna L. Berry

Personal Patient Profile-Prostate: Testing and Implementation in Health Networks

Prostate

Radiation Oncology Surgery / Surgical oncology

Deborah Schrag

Partnerships Between Medicaid, Tumor Registries & Cancer Control Researchers

Melanoma of skin All cancers but non-melanoma skin cancer

Levi A. Garraway

Overcoming resistance to targeted therapy in cancer

Melanoma of skin All cancers but non-melanoma skin cancer

Donald W. Kufe

Oncogenic Signaling by DF3/MUC1 in Human Breast Cancer

Breast

Adam Joel Bass

Novel Roles for Oncogenic SOX2 in Esophageal Squamous Cell Carcinoma

Oesophagus

Massimo Loda

Molecular Link Between Metabolic Syndrome and Prostate Cancer

Prostate

Steven Thomas Poynter

Misassembled BAF complexes in human cancer: structural and functional consequences

Sarcoma

Reiko Nishihara

Lifestyle, genetics and colonoscopy for colorectal cancer prevention

Colorectum

Anthony G Letai

Investigation of therapeutic modulators of apoptotic priming in pancreatic cancer

Pancreas

Pathology

Alice Berger

Investigating the role of the small GTPase RIT1 in lung adenocarcinoma

Trachea, bronchus and lung

Alec Kimmelman

Investigating the Role of Autophagy in Pancreatic Cancer Radiation Resistance

Pancreas

Radiation Oncology

Alec Kimmelman

Investigating a Novel Glutamine Metabolism Pathway in Pancreatic Cancer

Pancreas

Kornelia Polyak

Intratumor heterogeneity underlying treatment resistance in HER2+ breast tumors

Breast

Michael J Eck

Inhibitor-sensitive and -resistant EGFR mutants from lung cancer and glioblastoma

Trachea, bronchus and lung Brain, nervous system

Kwok Kin Wong

In vivo analysis of EGFR mutant driven lung cancers responses to radiation therap

Trachea, bronchus and lung

Elsa Beyer Krall

Identifying STAT3 Co-dependencies in Cancer

Melanoma of skin All cancers but non-melanoma skin cancer

Meredith M Regan

IBCSG Statistical Center - A Breast Cancer Study Resource

Breast

Matthew L. Meyerson

How do genome alterations cause human lung cancer?

Trachea, bronchus and lung

Brendan D Price

Histone methylation controls activation of ATM and the radiation response

Melanoma of skin All cancers but non-melanoma skin cancer

Radiation Oncology

Jennifer L Guerriero

Harnessing anti-tumor macrophages for cancer therapy

Melanoma of skin All cancers but non-melanoma skin cancer

Robert J Mayer

Graduate Training in Cancer Research

Melanoma of skin All cancers but non-melanoma skin cancer

Hugo Aerts

Genotype and Imaging Phenotype Biomarkers in Lung Cancer

Trachea, bronchus and lung

Peter S Hammerman

Genomic Discovery and Targeted Therapeutics in Squamous Cell Lung Cancer

Trachea, bronchus and lung

Timothy R Rebbeck

Genetics of Prostate Cancer in Africa

Prostate

Toni Choueiri

Genetic Predictors of Response to mTOR inhibitors in advanced Renal Cancer

Kidney, renal pelvis and ureter

Rameen Beroukhim

Genetic evolution of glioblastomas during radiation and temozolomide therapy

Brain, nervous system

Donald W. Kufe

Functional role of the MUC1-C oncoprotein in non-small cell lung cancer

Trachea, bronchus and lung

Teru Hideshima

Functional and biologic significance of deacetylase3 inhibition in myeloma

Multiple myeloma and immunoproliferative diseases

Reginald D. Tucker-Seeley

Financial well-being following prostate cancer diagnosis

Prostate

Hugh S. Gannon

Extraordinary responder cell lines reveal unique targetable genetic dependencies

Breast

Franziska Michor

Evolution and Treatment Response of Brain, Breast, and Hematologic Malignancies

Non-Hodgkin lymphoma Leukaemia Hodgkin lymphoma Breast Brain, nervous system

Birgit Knoechel

Epigenetic mechanisms of drug resistance in T-cell acute lymphoblastic leukemia

Leukaemia

Bruce E. Johnson

EGFR Mutations in Non-Small Cell Lung Cancer

Trachea, bronchus and lung

David A. Frank

Dual STAT3/NF-kB Inhibitors for Targeted Cancer Therapy

Melanoma of skin All cancers but non-melanoma skin cancer

Loren David Walensky

Dissecting and Targeting Deregulated Mitochondrial Apoptosis in Human Cancer

Melanoma of skin All cancers but non-melanoma skin cancer

A. Thomas Look

Discovery of New Targets and Pathways for T-ALL Therapy

Leukaemia

Charles S Fuchs

Dietary And Lifestyle Determinants Of Colon Cancer Recurrence and Survival

Colorectum

Philip W Kantoff

DF/HCC SPORE in Prostate Cancer

Prostate

Nathanael Schiander Gray

Development of covalent PIP4K2 inhibitors for the treatment of p53 deficient lung tumors

Trachea, bronchus and lung

Nathanael Schiander Gray

Development and Application of Selective Covalent Cdk7 Inhibitors

Melanoma of skin All cancers but non-melanoma skin cancer

Xiaole Shirley Liu

Developing Informatics Technologies to Model Cancer Gene Regulation

Melanoma of skin All cancers but non-melanoma skin cancer

Jens G Lohr

Determining the mutational landscape of circulating multiple myeloma cells

Multiple myeloma and immunoproliferative diseases

Pathology

Peter S. Choi

Defining the role of RBM10 in RNA processing and tumor suppression

Melanoma of skin All cancers but non-melanoma skin cancer

Catherine Ju-Ying Wu

Defining the impact of clonal evolution on chronic lymphocytic leukemia

Leukaemia

Matthew L Freedman

Defining the epigenetic landscape in human prostate cancer

Prostate

Pathology

Margaret A Shipp

Complementary Signaling Pathways In Hodgkin Lymphoma and Related Malignancies

Hodgkin lymphoma

Pathology

Sandra J Lee

Comparative Assessment of Screening Strategies for Melanoma

Melanoma of skin

Ramesh A Shivdasani

Chromatin and transcriptional control of LGR5+ crypt base stem cells

Colorectum

Alexi A Wright

Chemotherapy Near Death: Modifiable Factors and Outcomes in Ovarian Cancer

Ovary

Christopher J Ott

Chemical Modulation of Chromatin Signaling in Lymphoid Malignancies

Non-Hodgkin lymphoma Leukaemia Hodgkin lymphoma

David Kozono

Characterization of lung cancer radiosensitizers from genome-wide RNAi screens

Trachea, bronchus and lung

Giovanni Luigi Parmigiani

Bioinformatics Tools for Genomic Analysis of Tumor and Stromal Pathways in Cancer

Melanoma of skin All cancers but non-melanoma skin cancer

Keith L Ligon

Assaying GBM growth and therapy response in single cells and tumorspheres (PQ17)

Brain, nervous system

Charles Roberts

Analysis of the role of the SWI/SNF complex in tumor suppression

Melanoma of skin All cancers but non-melanoma skin cancer

Carl D Novina

Analysis of cap-dependent translational repression by microRNAs in oncogenisis

Melanoma of skin All cancers but non-melanoma skin cancer

Shuji Ogino

Accelerating Transdisciplinary Epidemiology of Colorectal Cancer

Colorectum

Tina Yuan

A systematic dissection of oncogenic KRAS signaling for target identification and therapeutic development

Melanoma of skin All cancers but non-melanoma skin cancer

Joseph H Antin

A Randomized Trial of Tac/MTX/bortezomib vs Tac/MTXplacebo in Allogeneic HSCT

Non-Hodgkin lymphoma Leukaemia Hodgkin lymphoma

Ross I. Berbeco

A high efficiency imager for real-time lung cancer monitoring during radiotherapy

Trachea, bronchus and lung

Radiation Oncology

Matthew L Freedman

4C and Genome Editing for Causal SNP and Gene Discovery at Cancer Risk Loci

Melanoma of skin All cancers but non-melanoma skin cancer

Alexander Gimelbrant

(PQD4) Epigenetic loss of heterozygosity as a driver of the cancer field effect

Melanoma of skin All cancers but non-melanoma skin cancer

Catherine Ju-Ying Wu

(PQD1) lmpact of cytotoxic and targeted therapy on clonal evolution of CLL

Leukaemia

Carl D Novina

(PQD1) Evolution of vemurafenib resistance in circulating melanoma cells

Trachea, bronchus and lung

Pasi A Janne

Drug Resistance in Lung Cancer

Trachea, bronchus and lung

Michael James Hassett

Cancer Recurrence: Detection in Administrative Data, Incidence, and Costs

Trachea, bronchus and lung Prostate Colorectum Breast